KASUMI-1, ATCC CRL-2724

HL-60, ATCC CCL-240

THP-1, ATCC TIB-202

K-562, ATCC CCL-243

RS4;11, ATCC CRL-1873

MOLT-4, ATCC CRL-1582

CCRF-CEM, ATCC CCL-119

Biological understanding of top genetic alterations in leukemia

Validation and characterization of potential cancer driver genes

Functional profiling and molecular profiling of subtype-specific cancer cell lines

Testing small molecules or biologics for cancer drug development

A panel of 7 leukemia cell lines representing Acute Myeloid Leukemia (AML), Acute Monocytic Leukemia (AMoL), Chronic Myeloid Leukemia (CML), and Acute Lymphoblastic Leukemia (ALL). Each culture contains genomic mutations in one or more of the following genes according to the Sanger COSMIC database: CDKN2A, KDM6A, TP53, NRAS, NOTCH1, PTEN, FBXW7, FLT3, KRAS, MLH1, and PIK3R1.